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Understanding Isolated Systolic Hypertension Treatment Options

Medically reviewed by Jazmin N. McSwain, Pharm.D., BCPS
Written by Simi Burn, PharmD
Updated on July 10, 2025

Key Takeaways

  • Isolated systolic hypertension is the most common form of high blood pressure in older adults and occurs when systolic blood pressure is higher than 130 mm Hg but diastolic pressure remains below 80 mm Hg.
  • Heart valve disease, artery stiffness, diabetes, and obesity can increase the risk of isolated systolic hypertension, with older adults - particularly women and Black people - being at higher risk for developing this condition.
  • If you are diagnosed with isolated systolic hypertension, talk to your healthcare provider about treatment options, which may include medications like diuretics or ACE inhibitors, as well as lifestyle changes such as following a heart-healthy diet and exercising regularly.
  • View full summary

Isolated systolic hypertension is the most common form of hypertension (high blood pressure) in older people, and it’s a major risk factor for cardiovascular disease (heart disease). If you’ve been diagnosed with isolated systolic hypertension, your doctor may talk to you about medications and lifestyle changes to treat your condition.

What Is Isolated Systolic Hypertension?

When your medical provider checks your blood pressure, they measure two numbers. The first or top number — your systolic blood pressure — measures the pressure in your arteries when your heart beats. The second or bottom number — your diastolic blood pressure — measures the pressure in your arteries between beats, when your heart rests. Your medical provider will tell you your blood pressure reading as systolic “over” diastolic.

Normal blood pressure is a systolic pressure of less than 120 millimeters of mercury (abbreviated as mm Hg) and a diastolic blood pressure of less than 80 mm Hg. If your systolic blood pressure is higher than 130 mm Hg, but your diastolic pressure is less than 80 mm Hg, it’s called isolated systolic hypertension.

Isolated Systolic Hypertension Causes and Risk Factors

Heart conditions such as heart valve disease and artery stiffness can lead to isolated systolic hypertension. Diabetes, hyperthyroidism (overactive thyroid), and obesity are also associated with a risk of high blood pressure.

According to The American Journal of Medicine, older people — specifically, women and Black people — have a higher risk of developing isolated systolic hypertension. However, younger and middle-aged people can also develop it.

Certain lifestyle factors can increase your risk of high blood pressure, including:

  • Having a high sodium intake (eating a lot of salt)
  • Getting too little exercise
  • Drinking too much alcohol
  • Using tobacco products

Is Isolated Systolic Hypertension Dangerous?

It’s important to see your doctor for regular blood pressure monitoring. High blood pressure is sometimes called “the silent killer” because you probably won’t know you have it unless your medical provider tells you. Even without noticeable symptoms, hypertension can raise the risk of stroke, heart disease, and chronic kidney disease.

How Is Isolated Systolic Hypertension Treated?

Lowering high blood pressure is important to reduce your risk of serious illnesses. If you are diagnosed with isolated systolic hypertension, your healthcare provider may prescribe medication or recommend lifestyle changes. Some people also explore natural supplements to lower blood pressure, but these options should always be discussed with your doctor.

Medications for High Blood Pressure

Several types of drugs can treat high blood pressure. Your doctor may prescribe one or more medications for isolated systolic hypertension that work in different ways to help bring your blood pressure down. They’ll help you choose the best treatment option for your individual health needs.

If your doctor prescribes blood pressure medication, it’s important that you take it exactly as directed. Some medications should never be crushed, chewed, or cut in half. Don’t make changes or stop taking your medication without talking to your medical provider first.

Diuretics

Sometimes called “water pills,” diuretics help your body get rid of extra water and salt through your urine. Diuretics are often one of the first medications prescribed for isolated systolic hypertension. The three types of diuretics — thiazide, loop, and potassium-sparing — work on different parts of your kidneys.

A common side effect of diuretics is increased urination, so you may find yourself going to the bathroom more frequently. One MyHeartDiseaseTeam member said, “My doctor prescribed a water pill, and it’s causing me to run to the bathroom all day long!”

Other side effects of diuretics include dizziness, dehydration, and electrolyte changes in your blood.

If a diuretic doesn’t lower your blood pressure enough on its own, your doctor may add other medications.

ACE Inhibitors

Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure by causing blood vessels to relax. These medicines stop the body from making something called angiotensin 2 (sometimes written in Roman numerals as angiotensin II), which normally makes blood vessels tighten.

Side effects of ACE inhibitors include headache, dizziness, fatigue, dry cough, and hyperkalemia (high potassium in your blood).

In rare cases, ACE inhibitors can cause angioedema (facial and airway swelling), which is a serious medical emergency.

ACE inhibitors shouldn’t be used to treat high blood pressure or other heart problems during pregnancy.

Angiotensin-Receptor Blockers

Angiotensin-receptor blockers (ARBs) also lower blood pressure by relaxing your blood vessels, but they work in a different way. ARBs hold back the activity of angiotensin 2.

Side effects of ARBs include headache, dizziness, fatigue, and hyperkalemia. These drugs shouldn’t be used during pregnancy.

Calcium Channel Blockers

Calcium channel blockers reduce blood pressure by keeping calcium out of the heart’s cells and arteries, allowing blood vessels to relax and open. Calcium channel blockers can lead to side effects such as dizziness, upset stomach, fatigue, and swelling of your ankles or legs.

Beta-Blockers

Beta-blockers help your heart beat more slowly and with less force. However, these drugs aren’t usually a first-line treatment for high blood pressure in people over 60 — they often don’t work as effectively in older adults as they do in younger people. Doctors might prescribe them as a first-line treatment in specific cases based on a person’s medical history.

Common side effects of beta-blockers include fatigue, headache, stomach upset, and dizziness. In rare cases, beta-blockers can cause slow heartbeat, confusion, or problems with breathing.

Lifestyle Changes for High Blood Pressure

Making certain lifestyle changes may help control blood pressure. If you have high blood pressure, your doctor may recommend that you adopt some heart-healthy habits. You might be advised to:

  • Eat a diet rich in fresh fruits and vegetables, whole grains, and lean protein.
  • Eat foods low in sodium and saturated fat.
  • Stop smoking tobacco or using nicotine.
  • Limit alcohol (if you drink). The Centers for Disease Control and Prevention (CDC) recommend no more than two drinks per day for men and no more than one per day for women.
  • Exercise regularly for about 30 minutes a day, five days a week. Choose moderate-intensity activities such as brisk walking, swimming, or bicycling.
  • Get enough sleep.
  • Reduce and manage stress.

MyHeartDiseaseTeam members encourage each other in making heart-healthy lifestyle changes. One member said, “Stick with that diet. It’s tough at times but worth it.”

Another wrote, “Some days we get the exercise we need, and some days we just can’t for whatever reason. Just don’t beat yourself up. Do what you can when you can, and just take the best care of yourself possible.”

Talk With Others Who Understand

MyHeartDiseaseTeam is the social network for people with heart disease and their loved ones. On MyHeartDiseaseTeam, members come together to ask questions, give advice, and share their stories with others who understand life with heart disease.

Are you living with isolated systolic hypertension? Are you taking any medications or making lifestyle changes to help manage your condition? Share your experience and tips in the comments below or by posting on your Activities page.

References
  1. Isolated Systolic Hypertension: An Update After Sprint — The American Journal of Medicine
  2. Isolated Systolic Hypertension: A Health Concern? — Mayo Clinic
  3. About High Blood Pressure — Centers for Disease Control and Prevention
  4. Blood Pressure Chart: What Your Reading Means — Mayo Clinic
  5. High Blood Pressure Risk Factors — Centers for Disease Control and Prevention
  6. What Is High Blood Pressure? — American Heart Association
  7. Health Threats From High Blood Pressure — American Heart Association
  8. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines — Journal of the American College of Cardiology
  9. Medication Management — American Heart Association
  10. Diuretics — Cleveland Clinic
  11. Therapeutic Uses of Diuretic Agents — StatPearls
  12. Diuretics — Mayo Clinic
  13. ACE Inhibitors — StatPearls
  14. ACE Inhibitors — Cleveland Clinic
  15. Angiotensin II Receptor Blockers (ARB) — StatPearls
  16. Calcium Channel Blockers — StatPearls
  17. Calcium Channel Blockers — Cleveland Clinic
  18. Beta Blockers — StatPearls
  19. Re-Examining the Efficacy of Beta-Blockers for the Treatment of Hypertension: A Meta-Analysis — Canadian Medical Association Journal
  20. 2023 ESH Hypertension Guideline Update: Bringing Us Closer Together Across the Pond — American College of Cardiology
  21. Preventing High Blood Pressure — Centers for Disease Control and Prevention​​
  22. Understanding Blood Pressure Readings — American Heart Association

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